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Victor M Rivera Selected Research

ponatinib

1/2022Phase II Study of Ponatinib in Advanced Gastrointestinal Stromal Tumors: Efficacy, Safety, and Impact of Liquid Biopsy and Other Biomarkers.
7/2018RET fusions observed in lung and colorectal cancers are sensitive to ponatinib.
1/2018Ponatinib efficacy and safety in Philadelphia chromosome-positive leukemia: final 5-year results of the phase 2 PACE trial.
4/2016The impact of multiple low-level BCR-ABL1 mutations on response to ponatinib.
1/2016Ponatinib versus imatinib for newly diagnosed chronic myeloid leukaemia: an international, randomised, open-label, phase 3 trial.
11/2014Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and shows therapeutic potential in heavily pretreated gastrointestinal stromal tumor (GIST) patients.
5/2013Combined targeting of FGFR2 and mTOR by ponatinib and ridaforolimus results in synergistic antitumor activity in FGFR2 mutant endometrial cancer models.
11/2012Ponatinib in refractory Philadelphia chromosome-positive leukemias.
3/2012Ponatinib (AP24534), a multitargeted pan-FGFR inhibitor with activity in multiple FGFR-amplified or mutated cancer models.
11/2011The BCR-ABL35INS insertion/truncation mutant is kinase-inactive and does not contribute to tyrosine kinase inhibitor resistance in chronic myeloid leukemia.
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Victor M Rivera Research Topics

Disease

23Neoplasms (Cancer)
10/2021 - 02/2002
18Multiple Sclerosis
12/2019 - 02/2002
13BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
11/2018 - 10/2004
4Lung Neoplasms (Lung Cancer)
10/2021 - 05/2011
4Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2021 - 12/2011
4Leukemia
11/2018 - 11/2012
4Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
01/2018 - 05/2008
3Disease Progression
03/2020 - 02/2009
3Philadelphia Chromosome
01/2018 - 11/2012
3Lymphoma (Lymphomas)
01/2016 - 05/2008
2Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor)
01/2022 - 11/2014
2Pancreatitis
01/2016 - 11/2012
2Relapsing-Remitting Multiple Sclerosis
12/2013 - 07/2013
2Endometrial Neoplasms (Endometrial Cancer)
05/2013 - 10/2011
2Sarcoma (Soft Tissue Sarcoma)
01/2012 - 10/2011
2Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
06/2011 - 05/2008
2Hematologic Neoplasms (Hematological Malignancy)
06/2011 - 05/2008
1Pulmonary Embolism
01/2022
1Pneumonia (Pneumonitis)
01/2022
1Adenocarcinoma of Lung
10/2021
1Neuromyelitis Optica (Devic's Disease)
08/2021
1Nervous System Diseases (Neurological Disorders)
12/2019
1Colorectal Neoplasms (Colorectal Cancer)
07/2018
1Neoplasm Metastasis (Metastasis)
12/2016
1Hypertension (High Blood Pressure)
12/2016
1Neuroblastoma
05/2016
1Atrial Fibrillation
01/2016
1Arterial Occlusive Diseases (Arterial Occlusive Disease)
01/2016
1Neutropenia
01/2016
1Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma)
01/2016
1Thrombocytopenia (Thrombopenia)
01/2016
1Exanthema (Rash)
01/2016
1Chronic Progressive Multiple Sclerosis
07/2013
1Cardiotoxicity
07/2013
1Prostatic Neoplasms (Prostate Cancer)
08/2012
1Glioma (Gliomas)
04/2012
1Blast Crisis (Blast Phase)
05/2008
1Mantle-Cell Lymphoma (Lymphoma, Mantle Cell)
05/2008
1Myelodysplastic Syndromes (Myelodysplastic Syndrome)
05/2008
1Primary Myelofibrosis (Myelosclerosis)
05/2008
1B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
05/2008
1T-Cell Leukemia (Leukemia, T Cell)
05/2008
1Glioblastoma (Glioblastoma Multiforme)
05/2007
1Progressive Multifocal Leukoencephalopathy
06/2006
1Parkinson Disease (Parkinson's Disease)
01/2006
1Hyperglycemia
01/2005

Drug/Important Bio-Agent (IBA)

12ponatinibIBA
01/2022 - 11/2009
11ridaforolimusIBA
05/2013 - 01/2008
10Tyrosine Kinase InhibitorsIBA
10/2021 - 11/2011
10Phosphotransferases (Kinase)IBA
02/2016 - 11/2009
5CrizotinibIBA
12/2016 - 05/2011
5brigatinibIBA
12/2016 - 05/2011
5Anaplastic Lymphoma KinaseIBA
12/2016 - 12/2011
5TOR Serine-Threonine KinasesIBA
04/2012 - 01/2008
5Sirolimus (Rapamycin)FDA Link
10/2011 - 08/2002
5Myelin Basic ProteinIBA
04/2004 - 02/2002
4Biomarkers (Surrogate Marker)IBA
01/2022 - 07/2004
4Imatinib Mesylate (Gleevec)FDA Link
01/2016 - 11/2009
4Interferon-betaIBA
06/2006 - 04/2003
3Pharmaceutical PreparationsIBA
11/2018 - 02/2009
3nilotinibFDA Link
01/2018 - 11/2009
3Dasatinib (BMS 354825)FDA Link
01/2018 - 11/2009
3Lipase (Acid Lipase)FDA Link
12/2016 - 11/2012
2mobocertinibIBA
10/2021 - 01/2021
2Biosimilar PharmaceuticalsIBA
12/2019 - 03/2010
2Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA
01/2016 - 05/2011
2Proteins (Proteins, Gene)FDA Link
01/2012 - 06/2002
2AutoantigensIBA
04/2004 - 03/2004
1Ado-Trastuzumab EmtansineIBA
10/2021
1Immunoconjugates (Immunoconjugate)IBA
10/2021
1AntibodiesIBA
08/2021
1Biological ProductsIBA
11/2018
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
05/2016
1EnzymesIBA
01/2016
1Oncogene Proteins (Oncogene Protein)IBA
11/2014
1Mitoxantrone (Novantrone)FDA LinkGeneric
07/2013
1Drug CombinationsIBA
05/2013
1AmylasesFDA Link
11/2012
1AndrogensIBA
08/2012
1bicalutamide (Casodex)FDA LinkGeneric
08/2012
1Androgen Antagonists (Antiandrogens)IBA
08/2012
1Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA
03/2012
1DCC-2036IBA
11/2011
1tovaxinIBA
07/2011
1Type 1 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 1)IBA
06/2011
1Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA
06/2011
1NVP-TAE684IBA
05/2011
1Adrenal Cortex Hormones (Corticosteroids)IBA
01/2011
1ProdrugsIBA
10/2010
1Capecitabine (Xeloda)FDA Link
10/2010
1Interferon beta-1aFDA Link
04/2010
1CholesterolIBA
02/2009
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
05/2007
1Aromatic-L-Amino-Acid DecarboxylasesIBA
01/2006
1bcr-abl Fusion ProteinsIBA
10/2004

Therapy/Procedure

16Therapeutics
10/2021 - 02/2002
1Castration
08/2012
1Intravenous Infusions
01/2012
1Immunotherapy
07/2011
1Transplantation
01/2005